منابع مشابه
The polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
متن کاملN-glycosyl derivatives of polyene macrolide antibiotics.
Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...
متن کاملChemistry and biology of the polyene macrolide antibiotics.
[This corrects the article on p. 166 in vol. 37, PMID: 4578757.].
متن کاملThe synthesis of amides of polyene macrolide antibiotics.
groups activated under the treatment with diphenyl phosphorazidate7) and triethylamine or N,N'-dicyclohexylcarbodiimide and I-hydroxy1 H-benzotriazole mixtures. The reaction was carried out in N,N-dimethylformamide or N,Ndimethylacetamide, at room temperature, using an excess of the reagents. The course of the reaction was followed by means of thin-layer chromatography on silica gel with the so...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1979
ISSN: 0032-5473
DOI: 10.1136/pgmj.55.647.653